Promethazine dosage and use

Promethazine dosage and use

Promethazine Dosage Forms & Strengths

Tablet

  • 12.5mg
  • 25mg
  • 50mg

suppository

  • 12.5mg
  • 25mg
  • 50mg

injectable solution

  • 25mg/mL
  • 50 mg/mL

syrup

  • 6.25mg/5mL
 

Allergic Conditions

PO/PR: 25 mg at bedtime or 12.5 mg before meals and at bedtime (dosage range, 6.25-12.5 mg q8hr)

IV/IM: 25 mg; may be repeated in 2 hours when necessary; switch to PO as soon as possible

Nausea & Vomiting

PO/PR: 12.5-25 mg q4-6hr PRN

IV/IM: 12.5-25 mg q4-6hr PRN

Motion Sickness

25 mg PO/PR 30-60 minutes before departure and q8-12hr PRN; on succeeding travel days, 25 mg PO/PR every morning and every evening

Preoperative Sedation

50 mg PO/PR on night before procedure or 25-50 mg IV/IM combined with reduced doses of analgesics and atropinelike drugs

Postoperative Sedation

25-50 mg IV/IM/PO/PR combined with reduced doses of analgesics and atropinelike drugs

Obstetric Sedation

25-50 mg IV/IM in early labor; may be increased to 25-75 mg q2-4hr after labor established; not to exceed two doses or up to 100 mg/day during labor

Dosage Forms & Strengths

Tablet

  • 12.5mg
  • 25mg
  • 50mg

suppository

  • 12.5mg
  • 25mg
  • 50mg

injectable solution

  • 25mg/mL

syrup

  • 6.25mg/5mL
 

Allergic Conditions (Off-label)

<2 years old: Contraindicated

≥2 years old: 25 mg PO/PR at bedtime or 12.5 mg q6hr; alternatively, 6.25-12.5 mg PO/PR q8hr

Nausea & Vomiting

<2 years old: Contraindicated

≥2 years old: 0.25-1 mg/kg PO/PR q4-6hr PRN; not to exceed 25 mg 

Motion Sickness

<2 years: Contraindicated

≥2 years: 12.5-25 mg PO/PR administered 30-60 minutes before departure and q8-12hr PRN or 0.5 mg/kg PO q12hr PRN 

Succeeding days of travel: 12.5-25 mg twice daily (upon arising or before evening meals)

Sedation

<2 years: Contraindicated

≥2 years: 12.5-25 mg PO/IM/PR at bedtime

Preoperative Sedation

<2 years: Contraindicated

≥2 years: 1 mg/kg PO/PR with reduced dose of analgesic and appropriate dose of atropinelike drug  

Postoperative Sedation

<2 years: Contraindicated

≥2 years: 12.5-25 mg with reduced dose of analgesic and appropriate dose of atropinelike drug

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